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Cohort selection. CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; ICD, International Classification of Diseases; LCED, <t>Explorys</t> <t>Linked</t> <t>Claims</t> and Electronic Medical Records Data; LPD, Longitudinal Patient Database; RWD, Real World Data; THIN, The Health Improvement Network.
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Cohort selection. CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; ICD, International Classification of Diseases; LCED, Explorys Linked Claims and Electronic Medical Records Data; LPD, Longitudinal Patient Database; RWD, Real World Data; THIN, The Health Improvement Network.

Journal: BMJ Open

Article Title: Prevalence of undiagnosed stage 3 chronic kidney disease in France, Germany, Italy, Japan and the USA: results from the multinational observational REVEAL-CKD study

doi: 10.1136/bmjopen-2022-067386

Figure Lengend Snippet: Cohort selection. CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; ICD, International Classification of Diseases; LCED, Explorys Linked Claims and Electronic Medical Records Data; LPD, Longitudinal Patient Database; RWD, Real World Data; THIN, The Health Improvement Network.

Article Snippet: The prevalence of undiagnosed stage 3 CKD was 95.5% (19 120/20 012 patients) in France, 84.3% (22 557/26 767) in Germany, 77.0% (50 547/65 676) in Italy, 92.1% (83 693/90 902) in Japan, 61.6% (13 845/22 470) in the US Explorys Linked Claims and Electronic Medical Records Data database and 64.3% (161 254/250 879) in the US TriNetX database.

Techniques: Selection, Filtration

Prevalence of undiagnosed stage 3 CKD according to country and database (A) overall and (B) by sex. Undiagnosed cases are those that lack a diagnosis code for CKD (any stage), any time before and up to 6 months after study index. CKD, chronic kidney disease; LCED, Explorys Linked Claims and Electronic Medical Records Data.

Journal: BMJ Open

Article Title: Prevalence of undiagnosed stage 3 chronic kidney disease in France, Germany, Italy, Japan and the USA: results from the multinational observational REVEAL-CKD study

doi: 10.1136/bmjopen-2022-067386

Figure Lengend Snippet: Prevalence of undiagnosed stage 3 CKD according to country and database (A) overall and (B) by sex. Undiagnosed cases are those that lack a diagnosis code for CKD (any stage), any time before and up to 6 months after study index. CKD, chronic kidney disease; LCED, Explorys Linked Claims and Electronic Medical Records Data.

Article Snippet: The prevalence of undiagnosed stage 3 CKD was 95.5% (19 120/20 012 patients) in France, 84.3% (22 557/26 767) in Germany, 77.0% (50 547/65 676) in Italy, 92.1% (83 693/90 902) in Japan, 61.6% (13 845/22 470) in the US Explorys Linked Claims and Electronic Medical Records Data database and 64.3% (161 254/250 879) in the US TriNetX database.

Techniques: Biomarker Discovery

Prevalence of undiagnosed stage 3 CKD according to the presence of comorbidities at study index, by country and database. Established CVD includes patients with a history of myocardial infarction, unstable angina, stroke, transient ischaemic attack, coronary artery bypass graft and percutaneous coronary intervention. Study index is defined as the date of a patient’s second qualifying eGFR measurement. *Owing to a lack of granularity for ICD-9 diagnostic codes in the database used, type of diabetes could not be determined in patients from Italy. †Owing to a lack of granularity for ICD-9 codes in the database used, established CVD does not include coronary artery bypass graft and percutaneous coronary intervention in patients from Italy. CKD, chronic kidney disease; CVD, cardiovascular disease; eGFR, estimated glomerular filtration rate; ICD-9, International Classification of Diseases 9; LCED, Explorys Linked Claims and Electronic Medical Records Data.

Journal: BMJ Open

Article Title: Prevalence of undiagnosed stage 3 chronic kidney disease in France, Germany, Italy, Japan and the USA: results from the multinational observational REVEAL-CKD study

doi: 10.1136/bmjopen-2022-067386

Figure Lengend Snippet: Prevalence of undiagnosed stage 3 CKD according to the presence of comorbidities at study index, by country and database. Established CVD includes patients with a history of myocardial infarction, unstable angina, stroke, transient ischaemic attack, coronary artery bypass graft and percutaneous coronary intervention. Study index is defined as the date of a patient’s second qualifying eGFR measurement. *Owing to a lack of granularity for ICD-9 diagnostic codes in the database used, type of diabetes could not be determined in patients from Italy. †Owing to a lack of granularity for ICD-9 codes in the database used, established CVD does not include coronary artery bypass graft and percutaneous coronary intervention in patients from Italy. CKD, chronic kidney disease; CVD, cardiovascular disease; eGFR, estimated glomerular filtration rate; ICD-9, International Classification of Diseases 9; LCED, Explorys Linked Claims and Electronic Medical Records Data.

Article Snippet: The prevalence of undiagnosed stage 3 CKD was 95.5% (19 120/20 012 patients) in France, 84.3% (22 557/26 767) in Germany, 77.0% (50 547/65 676) in Italy, 92.1% (83 693/90 902) in Japan, 61.6% (13 845/22 470) in the US Explorys Linked Claims and Electronic Medical Records Data database and 64.3% (161 254/250 879) in the US TriNetX database.

Techniques: Diagnostic Assay, Filtration

Kaplan-Meier estimates of time to CKD diagnosis according to country and database in patients undiagnosed at index, overall and by CKD stage (3a/3b). Shaded areas represent 95% confidence intervals. CKD, chronic kidney disease; LCED, Explorys Linked Claims and Electronic Medical Records Data.

Journal: BMJ Open

Article Title: Prevalence of undiagnosed stage 3 chronic kidney disease in France, Germany, Italy, Japan and the USA: results from the multinational observational REVEAL-CKD study

doi: 10.1136/bmjopen-2022-067386

Figure Lengend Snippet: Kaplan-Meier estimates of time to CKD diagnosis according to country and database in patients undiagnosed at index, overall and by CKD stage (3a/3b). Shaded areas represent 95% confidence intervals. CKD, chronic kidney disease; LCED, Explorys Linked Claims and Electronic Medical Records Data.

Article Snippet: The prevalence of undiagnosed stage 3 CKD was 95.5% (19 120/20 012 patients) in France, 84.3% (22 557/26 767) in Germany, 77.0% (50 547/65 676) in Italy, 92.1% (83 693/90 902) in Japan, 61.6% (13 845/22 470) in the US Explorys Linked Claims and Electronic Medical Records Data database and 64.3% (161 254/250 879) in the US TriNetX database.

Techniques: Biomarker Discovery